The 2021 Southwest Adaptation Forum took place in April 2021 and was co-convened with the Climate Science Alliance (CSA). Building on takeaways from the 2018 Forum, the 2021 SWAF convened leaders, practitioners, and researchers from across the Southwest to explore efforts advancing climate change adaptation and resilience. Unique to the 2021 SWAF was the Tribal Advisory Committee, made up of tribal environmental professionals representing a diverse composition of Indigenous Nations across Southwest states, who led the visioning for the event. Over the course of 3 days, adaptation professionals interacted in 22 sessions, with presentations, panel discussions, and a powerful, interactive training for scientists and practitioners working with, or looking to collaborate with, Indigenous Communities.